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Enclomiphene

Enclomiphene is a SERM (selective estrogen receptor antagonist) that causes the testes to produce more testosterone without impacting sperm production, making it a testosterone-boosting alternative for men looking to preserve their fertility.

  • Heightened libido
  • Increased muscle strength
  • Enhanced energy
  • Better blood sugar control
  • Improved erectile function
  • Increased lean body mass
  • Improved mood
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Why Choose DIRECT MEDS Rx?

  • No hidden fees or confusing pricing
  • Direct access to dedicated treatment specialists
  • Fast, transparent prescription and consultation process
  • Flexible, no-commitment treatment plans

What is Enclomiphene?

Enclomiphene is a selective estrogen blocker that attaches to estrogen receptors in the brain. This action boosts levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn stimulates testosterone production in the testes. Unlike testosterone replacement therapy, enclomiphene does not hinder FSH and LH hormones or sperm production.

Heightened libido and improved erectile function

In a study of 52 men with low-T, enclomiphene raised testosterone levels within six weeks. FSH and LH levels remained stable, as did sperm count. Researchers believe that replenishing testosterone levels can boost libido and erectile function in 3 to 6 weeks.

Increased muscle strength and lean body mass

Enclomiphene increases testosterone levels in about 6 weeks without affecting FSH and LH levels or sperm count. Restoring testosterone levels is likely to increase lean body mass in about 12 to 16 weeks and increase muscle strength within 12 to 16 weeks.

Enhanced energy and mood

In a small study involving men with low testosterone, enclomiphene was found to enhance testosterone levels within approximately six weeks. Larger studies support these results. Boosting testosterone levels can improve energy, mood, and vitality in men experiencing symptoms related to low testosterone within 3 to 6 months.

Better blood sugar control

The results of a small study conducted on men with low testosterone found that enclomiphene could raise testosterone levels within about six weeks. Boosting testosterone levels can increase insulin sensitivity within a few days and improve blood sugar control over 3 to 12 months.

How to Use Enclomiphene

Use as directed by your physician.

Enclomiphene Side Effects

  • Headache
  • Hot Flashes
  • Muscle spasms/joint pain
  • Nausea
  • Cold symptoms
  • Diarrhea

Frequently Asked Questions about Enclomiphene

Enclomiphene blocks estrogen receptors in the brain. This enables the pituitary gland to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH) even as testosterone levels increase in the body.

Enclomiphene works with your body’s natural feedback loops to boost your testosterone levels while preserving your fertility.

No, enclomiphene is not a steroid. It is a non-steroidal selective estrogen receptor antagonist. It blocks the effects of estrogen and increases testosterone production.

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.

When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

The FDA stated that the design of the enclomiphene phase 3 studies was no longer adequate to show clinical benefit. They showed that enclomiphene increased testosterone levels but did not show how an increased testosterone level provided benefits such as increased muscle strength, improved sexual function, and decreased fatigue.

 

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis. It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.
Yes, enclomiphene can increase your hematocrit (the proportion of red blood cells in your bloodstream) and your risk for venous thromboembolism (blood clots). These are known risks when increasing testosterone levels. Have your hematocrit checked before starting enclomiphene and periodically after you begin taking the medication. If you have a family history of blood clots or risk factors for blood clots, discuss this increased risk with your doctor.

Yes, obesity and being overweight are linked to low testosterone levels. Body fat contains aromatases that convert testosterone to estrogens.

When estrogen levels increase, they reduce FSH and LH release. FSH and LH are essential for testosterone production and sperm maturation. When FSH and LH levels decline, testosterone production does as well.

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